TACA

Contact us

Yadi Zhou, PhD

Senior Data Scientist, Developer
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic
[email protected]

Feixiong Cheng, PhD

Principal Investigator, Assistant Professor
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic
Phone: (216) 444-7654
[email protected]
https://www.lerner.ccf.org/gmi/cheng/

Add datasets

Please contact us if we have missed your datasets. A processed .rds file that has the Seurat object of the dataset (including cell type annotations) and a detailed metadata table will suffice.

Cite

The Alzheimer's Cell Atlas (TACA): A single-cell molecular map for target identification and drug repurposing in Alzheimer's disease Zhou Y, Xu J, Hou Y, Bekris L, Leverenz, JB, Pieper AA, Cummings J, Cheng F 2022. Submitted.

References

Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease Fang J, Zhang P, Zhou Y, Chiang CW, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, Cheng F Nat Aging. 2021;1:1175-1188. PubMed | PMC

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease Fang J, Zhang P, Wang Q, Chiang CW, Zhou Y, Hou Y, Xu J, Chen R, Zhang B, Lewis SJ, Leverenz, JB, Pieper AA, Li B, Li L, Cummings J, Cheng F Alzheimers Res Ther. 2022;14(1):7. PubMed | PMC

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery Zhou Y, Fang J, Bekris L, Kim YH, Pieper AA, Leverenz J, Cummings J, Cheng F Alzheimers Res Ther. 2021;13(1):24. PubMed | PMC

Harnessing endophenotypes and using network medicine in Alzheimer's drug repurposing Fang J, Pieper AA, Bekris L, Lee G, Nussinov R, Leverenz J, Cummings J, Cheng F Medicinal Research Reviews. 2020;40(6):2386-2426. PubMed | PMC

A genome-wide positioning systems network algorithm for in silico drug repurposing Cheng F, Lu W, Liu C, Fang J, Hou Y, Handy D, Wang R, Zhao Y, Yang Y, Huang J, Hill D, Vidal M, Eng C, Loscalzo J Nat Commun. 2019;10:3476. PubMed | PMC

Alzheimer's disease drug development pipeline: 2021 Cummings J, Lee G, Zhong K, Fonseca J, Taghva K Alzheimers Dement (N Y). 2021;7:e12179. PubMed | PMC

Alzheimer's disease drug development pipeline: 2020 Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K Alzheimers Dement (N Y). 2020;6:e12050. PubMed | PMC

Alzheimer's disease drug development pipeline: 2019 Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K Alzheimers Dement (N Y). 2019;5:272-293. PubMed | PMC

Alzheimer's disease drug development pipeline: 2018 Cummings J, Lee G, Ritter A, Zhong K Alzheimers Dement (N Y). 2018;4:195-214. PubMed | PMC