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TACAGENE / DRUG EXPLORER

RESULTS

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Gene page

This page shows the basic information of the selected gene.

Drug page

This page shows the basic information of the selected drug.

Sub dataset
Design
Abstract
Organism
Type
Year
Count
Cell types

Gene Overview

Gene
Name
Type
Alias

Quantitative Trait Locus (Beta > 0)

SNP ID	Beta	S.E.	P	SOURCE
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Quantitative Trait Locus (Beta < 0)

SNP ID	Beta	S.E.	P	SOURCE
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Drug Overview

Drug
Type
Groups
ATC
SMILES

Protein-Protein Interaction Network Drug-Target Network

PLOT CONTROL

LEGEND

~~Center gene~~

~~PPI neighbor~~

~~Protein-protein interaction~~

~~Drug~~

~~Drug target~~

~~Drug-target interaction~~

~~Protein-protein interaction~~

QTL Dataset # 1
Name	pQTL_ROSMAP_DLPFC
Type	pQTL
Year	2021
Cohort	ROSMAP
Brain Region	Dorsolateral Prefrontal Cortex
Sample	NCI, MCI, and AD
Reference	Genetic control of the human brain proteome. Am J Hum Genet. 2021;108(3):400-410.
PubMed	33571421
Source	https://www.synapse.org/#!Synapse:syn24847777

QTL Dataset # 2
Name	pQTL_ROSMAP_NCI_DLPFC
Type	pQTL
Year	2021
Cohort	ROSMAP
Brain Region	Dorsolateral Prefrontal Cortex
Sample	NCI only
Reference	Genetic control of the human brain proteome. Am J Hum Genet. 2021;108(3):400-410.
PubMed	33571421
Source	https://www.synapse.org/#!Synapse:syn24847777

QTL Dataset # 3
Name	pQTL_BannerBBDP_DLPFC
Type	pQTL
Year	2021
Cohort	Banner BBDP
Brain Region	Dorsolateral Prefrontal Cortex
Sample	NCI, MCI, and AD
Reference	Genetic control of the human brain proteome. Am J Hum Genet. 2021;108(3):400-410.
PubMed	33571421
Source	https://www.synapse.org/#!Synapse:syn24847777

QTL Dataset # 4
Name	eQTL_Cortex_MetaAnalysis
Type	eQTL
Year	2020
Cohort	Multiple
Brain Region	Dorsolateral Prefrontal Cortex
Sample
Reference	Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions. Sci Data. 2020;7(1):340.
PubMed	33046718
Source	https://www.synapse.org/#!Synapse:syn17015233

QTL Dataset # 5
Name	eQTL_DLPFC_ROSMAP
Type	eQTL
Year	2020
Cohort	ROSMAP
Brain Region	Dorsolateral Prefrontal Cortex
Sample
Reference	Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions. Sci Data. 2020;7(1):340.
PubMed	33046718
Source	https://www.synapse.org/#!Synapse:syn17015233

QTL Dataset # 6
Name	eQTL_CER_Mayo
Type	eQTL
Year	2020
Cohort	Mayo RNAseq
Brain Region	Cerebellum
Sample
Reference	Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions. Sci Data. 2020;7(1):340.
PubMed	33046718
Source	https://www.synapse.org/#!Synapse:syn17015233

QTL Dataset # 7
Name	eQTL_TCX_Mayo
Type	eQTL
Year	2020
Cohort	Mayo RNAseq
Brain Region	Temporal Cortex
Sample
Reference	Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions. Sci Data. 2020;7(1):340.
PubMed	33046718
Source	https://www.synapse.org/#!Synapse:syn17015233

QTL Dataset # 8
Name	eQTL_MetaBrain_BasalGanglia-EUR
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Basal Ganglia
Sample	EUR
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 9
Name	eQTL_MetaBrain_Cerebellum-EUR
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Cerebellum
Sample	EUR
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 10
Name	eQTL_MetaBrain_Cortex-EUR
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Cortex
Sample	EUR
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 11
Name	eQTL_MetaBrain_Hippocampus-EUR
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Hippocampus
Sample	EUR
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 12
Name	eQTL_MetaBrain_SpinalCord-EUR
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Spinal Cord
Sample	EUR
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 13
Name	eQTL_MetaBrain_Cortex-AFR
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Cortex
Sample	AFR
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 14
Name	eQTL_MetaBrain_Cortex-EAS
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Cortex
Sample	EAS
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 15
Name	eQTL_MetaBrain_Cortex-EUR-AFR-NoENA-NoPCA
Type	eQTL
Year	2021
Cohort	Multiple
Brain Region	Cortex
Sample	EUR-AFR-NoENA
Reference	Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases. bioRxiv 2021.03.01.433439
PubMed
Source	https://www.biorxiv.org/content/10.1101/2021.03.01.433439v2.supplementary-material

QTL Dataset # 16
Name	eQTL_Microglia_MFG
Type	eQTL
Year	2022
Cohort	NBB
Brain Region	Medial Frontal Gyrus (MFG)
Sample	Neurodegenerative, neurological, or neuropsychiatric disorders, and unaffected controls
Reference	Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet. 2022;54(1):4-17.
PubMed	34992268
Source	https://doi.org/10.5281/zenodo.4118605

QTL Dataset # 17
Name	eQTL_Microglia_STG
Type	eQTL
Year	2022
Cohort	NBB
Brain Region	Superior Temporal Gyrus (STG)
Sample	Neurodegenerative, neurological, or neuropsychiatric disorders, and unaffected controls
Reference	Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet. 2022;54(1):4-17.
PubMed	34992268
Source	https://doi.org/10.5281/zenodo.4118605

QTL Dataset # 18
Name	eQTL_Microglia_THA
Type	eQTL
Year	2022
Cohort	NBB
Brain Region	Thalamus (THA)
Sample	Neurodegenerative, neurological, or neuropsychiatric disorders, and unaffected controls
Reference	Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet. 2022;54(1):4-17.
PubMed	34992268
Source	https://doi.org/10.5281/zenodo.4118605

QTL Dataset # 19
Name	eQTL_Microglia_SVZ
Type	eQTL
Year	2022
Cohort	NBB
Brain Region	Subventricular Zone (SVZ)
Sample	Neurodegenerative, neurological, or neuropsychiatric disorders, and unaffected controls
Reference	Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet. 2022;54(1):4-17.
PubMed	34992268
Source	https://doi.org/10.5281/zenodo.4118605

The Alzheimer's Cell Atlas

A Single-Cell Type Transcriptomics and Network Pathobiology Map for Target Identification and Drug Repurposing

Gene page

Drug page

Gene Overview

Drug Overview

Protein-Protein Interaction Network Drug-Target Network